Go to Body

Extension of Coronavirus Disease 2019 (COVID-19) on Chest CT and Implications for Chest Radiograph Interpretation

페이지 정보

작성자 profile_imageadmin 작성일 20-04-02 16:08
288 0

본문

ABSTRACT 

Purpose:

To study the extent of pulmonary involvement in COVID-19 with quantitative CT (QCT) and to assess the impact of disease burden on opacity visibility on chest radiographs.


Materials and Methods:

This retrospective study included 20 pairs of CT scans and same-day chest radiographs from 17 patients with COVID-19, along with 20 chest radiographs of controls. All pulmonary opacities were semi-automatically segmented on CT images, producing an anteroposterior projection image to match the corresponding frontal chest radiograph. The lung opacification mass (QCTmass) was defined as [(opacity attenuation value+1000 HU)/1000]*1.065(g/mL) * combined volume (cm3) of the individual opacities. Eight thoracic radiologists reviewed the 40 radiographs, and a receiver operating characteristics curve analysis was performed for the detection of lung opacities. Logistic regression analysis was done to identify factors affecting opacity visibility on chest radiographs.


Results:

The mean QCTmass per patient was 72.4±120.8 g (range, 0.7-420.7), and opacities occupied 3.2±5.8% (range, 0.1-19.8) and 13.9±18.0% (range, 0.5-57.8) of the lung area on the CT images and projected images, respectively. The radiographs had a median sensitivity of 25% and specificity of 90% among radiologists. Nineteen of 186 opacities were visible on chest radiographs, and a median area of 55.8% of the projected images was identifiable on radiographs. Logistic regression analysis showed that QCTmass (p<0.001) and combined opacity volume (p<0.001) significantly affected opacity visibility on radiographs.


Conclusion:

QCTmass varied among COVID-19 patients. Chest radiographs had high specificity for detecting lung opacities in COVID-19, but a low sensitivity. QCTmass and combined opacity volume were significant determinants of opacity visibility on radiographs.


Summary:

Quantitative opacity mass and 3D opacity volume on CT were quantifiable metrics affecting the visibility of COVID-19-related opacities on chest radiographs.


Key Points:

■ In COVID-19 patients, considerable variation was found in the QCTmass (72.4±120.8 g; range, 0.7–420.7 g) and relative 3D opacity extent on CT (3.2±5.8% of lung area; range, 0.1–19.8%).

■ Chest radiographs in patients under investigation for COVID-19 provided a sensitivity of 25% (5/20) and specificity of 90% (18/20) for COVID-19-related opacities.

■ The QCTmass (p<.001) and the 3D opacity volume on CT (p<.001) significantly affected the visibility of COVID-19-related opacities on radiographs.



  • Company Name ㅣ MEDICALIP
    CEO ㅣ Sang Joon Park    Tel ㅣ +82-2-2135-9148
    Business Registration Number ㅣ 406-81-04085
    Address ㅣ 7F, Changgyeong Building, 174, Yulgok-ro, Jongno-gu, Seoul, Republic of Korea
Copyright2018. MEDICAL IP. All Rights Reserved.